A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis.

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Title: A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis.
Authors: Ediriwickrema A; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Biology Graduate Program, Stanford University, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Nakauchi Y; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Fan AC; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Immunology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA., Köhnke T; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Hu X; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA., Luca BA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA., Kim Y; Immunology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Ramakrishnan S; BD Biosciences, San Jose, CA 95131, USA., Nakamoto M; BD Biosciences, San Jose, CA 95131, USA., Karigane D; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Japan Society for the Promotion of Science, Tokyo, Japan., Linde MH; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Immunology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA., Azizi A; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Newman AM; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA., Gentles AJ; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA., Majeti R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: rmajeti@stanford.edu.
Source: Cell reports [Cell Rep] 2025 Sep 23; Vol. 44 (9), pp. 116236. Date of Electronic Publication: 2025 Sep 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.116236