Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.

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Title: Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.
Authors: Harvey ES; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia., Hamada Y; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan., Hiles SA; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; School of Psychological Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Langton D; Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia; Department of Thoracic Medicine, Frankston Hospital, Frankston, VIC, Australia., Thomas D; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., McDonald VM; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia., Bardin P; Lung and Sleep Medicine, Monash University and Medical Centre and Hudson Institute, Clayton, VIC, Australia., Peters M; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia., Reynolds PN; Lung Research Unit, Department of Thoracic Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia., Upham JW; Department of Respiratory Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Blakey J; Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia; Medical School, Curtin University, Perth, Western Australia, Australia., Bowler S; Department of Respiratory Medicine, Mater Hospital, Brisbane, QLD, Australia., Chien J; Department of Sleep and Respiratory Medicine, Westmead Hospital, Westmead, NSW, Australia; School of Medicine, The University of Sydney, Sydney, NSW, Australia., Chung LP; Department of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia., Farah CS; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia., Gillman A; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia., Harrington J; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia., Hew M; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Jenkins C; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia; Concord Clinical School, University of Sydney, Concord, NSW, Australia., Katelaris CH; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia; Immunology and Allergy Unit, Campbelltown Hospital, Campbelltown, NSW, Australia., Katsoulotos GP; Woolcock Institute of Medical Research, Sydney, NSW, Australia; St George Specialist Centre, Kogarah, NSW, Australia; St Vincent's Clinic, Darlinghurst, NSW, Australia; School of Medicine, Sydney Campus, University of Notre Dame, Australia., Kritikos V; Woolcock Institute of Medical Research, Sydney, NSW, Australia., Lee J; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Austin Health, Melbourne, VIC, Australia., Radhakrishna N; Respiratory Department, St Vincent's Hospital, Melbourne, VIC, Australia., Sivakumaran P; Department of Respiratory Medicine, Gold Coast University Hospital, Gold Coast, QLD, Australia., Wark PAB; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia; School of Translational Medicine, Monash University, VIC, Australia., Gibson PG; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia. Electronic address: peter.gibson@newcastle.edu.au.
Corporate Authors: Australian Mepolizumab Registry Investigators
Source: Respiratory medicine [Respir Med] 2025 Nov; Vol. 248, pp. 108340. Date of Electronic Publication: 2025 Sep 03.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-3064
DOI:10.1016/j.rmed.2025.108340