Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation.

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Title: Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation.
Authors: Yoo H; Bionsight, Inc., Chuncheon 24341, South Korea., Han SJ; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea., Lee JE; Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, South Korea., Cho C; Department of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea., Hong D; Bionsight, Inc., Chuncheon 24341, South Korea., Jeong B; Department of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea., Kim S; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea., Jung GY; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea., Ma M; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea., Jung S; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea., Park B; Bionsight, Inc., Chuncheon 24341, South Korea., Lee N; Bionsight, Inc., Chuncheon 24341, South Korea; Department of Information Statistics, Kangwon National University, Chuncheon 24341, South Korea., Yoo HS; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon 16499, South Korea., Cho KJ; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA., Seo MD; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon 16499, South Korea. Electronic address: mdseo@ajou.ac.kr., Chung Y; Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, South Korea. Electronic address: yeonseok@snu.ac.kr., Kim BS; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, South Korea. Electronic address: byungseokkim@inu.ac.kr., Yang H; Bionsight, Inc., Chuncheon 24341, South Korea; Department of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea. Electronic address: heejyang@kangwon.ac.kr.
Source: Journal of advanced research [J Adv Res] 2026 Jun; Vol. 84, pp. 1059-1071. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2090-1224
DOI:10.1016/j.jare.2025.09.004