Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease.

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Title: Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease.
Authors: Saaoud F; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Ben Issa M; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Liu L; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Center for Metabolic Disease Research and Thrombosis Research, Temple University, Philadelphia, PA, United States., Xu K; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Lu Y; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Shao Y; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Han B; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Jiang X; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States.; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Center for Metabolic Disease Research and Thrombosis Research, Temple University, Philadelphia, PA, United States., Liu X; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States., Gillespie A; Section of Nephrology, Hypertension, and Kidney Transplantation, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States., Luo JJ; Department of Neurology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States., Martinez L; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States., Vazquez-Padron R; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States., Mohsin S; Lewis Katz School of Medicine, Aging+Cardiovascular Discovery Center, Temple University, Philadelphia, PA, United States., Kosmider B; Lewis Katz School of Medicine, Center for Inflammation and Lung Research, Alzheimer's Center, Temple University, Philadelphia, PA, United States., Wang H; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Center for Metabolic Disease Research and Thrombosis Research, Temple University, Philadelphia, PA, United States., Fossati S; Lewis Katz School of Medicine, Alzheimer's Center, Temple University, Philadelphia, PA, United States., Yang X; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States.; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Center for Metabolic Disease Research and Thrombosis Research, Temple University, Philadelphia, PA, United States.
Source: Frontiers in molecular neuroscience [Front Mol Neurosci] 2025 Aug 22; Vol. 18, pp. 1605012. Date of Electronic Publication: 2025 Aug 22 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: In Process
Database: MEDLINE Ultimate
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ISSN:1662-5099
DOI:10.3389/fnmol.2025.1605012