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Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.

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Title: Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Authors: van der Wel AWT; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands., Frank CMC; Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands., Bout-Rebel R; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands., Duijnhoven RG; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Clinical Trials Unit of the Netherlands Society for Obstetrics and Gynaecology, Amsterdam, the Netherlands., van Bree BE; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands., Valkenburg O; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands., Al-Nasiry S; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands., van Oppenraaij RHF; Department of Obstetrics and Gynecology, Maasstad Hospital, Rotterdam, the Netherlands., Vogelvang TE; Department of Obstetrics and Gynecology, Diakonessenhuis Utrecht, Utrecht, the Netherlands., Westerhuis MEMH; Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, the Netherlands., van de Nieuwenhof HP; Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands., Gielen SCJP; Department of Obstetrics and Gynecology, Franciscus Gasthuis and Vlietland, Rotterdam, the Netherlands., Bandell ML; Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Bekker MN; Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands., Wouters MGAJ; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands., Mijatovic V; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Reproductive Medicine, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands., Franx A; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands., Lambalk CB; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Reproductive Medicine, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands., Broekmans FJM; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands.; Centre for Reproductive Medicine, Dijklander Ziekenhuis, Purmerend, the Netherlands., de Weerd S; Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Gerards JMH; Department of Obstetrics and Gynecology, Diakonessenhuis Utrecht, Utrecht, the Netherlands., Baalman JH; Department of Obstetrics and Gynecology, Medisch Spectrum Twente, Enschede, the Netherlands., van Disseldorp J; Department of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, the Netherlands., Langenveld J; Department of Obstetrics and Gynecology, Zuyderland MC, Heerlen, the Netherlands., Gunning MN; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands., Frederix GWJ; Department of Public Health, Julius Center Research Program Methodology, University Medical Centre Utrecht, Utrecht, the Netherlands., Painter RC; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands., Fauser BCJM; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands., Laven JSE; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands., van Rijn BB; Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, the Netherlands.; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Source: JAMA [JAMA] 2025 Oct 07; Vol. 334 (13), pp. 1151-1159.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22van+der+Wel+AWT%22">van der Wel AWT</searchLink>; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Frank+CMC%22">Frank CMC</searchLink>; Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bout-Rebel+R%22">Bout-Rebel R</searchLink>; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Duijnhoven+RG%22">Duijnhoven RG</searchLink>; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Clinical Trials Unit of the Netherlands Society for Obstetrics and Gynaecology, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Bree+BE%22">van Bree BE</searchLink>; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Valkenburg+O%22">Valkenburg O</searchLink>; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Al-Nasiry+S%22">Al-Nasiry S</searchLink>; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Oppenraaij+RHF%22">van Oppenraaij RHF</searchLink>; Department of Obstetrics and Gynecology, Maasstad Hospital, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vogelvang+TE%22">Vogelvang TE</searchLink>; Department of Obstetrics and Gynecology, Diakonessenhuis Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Westerhuis+MEMH%22">Westerhuis MEMH</searchLink>; Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Nieuwenhof+HP%22">van de Nieuwenhof HP</searchLink>; Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gielen+SCJP%22">Gielen SCJP</searchLink>; Department of Obstetrics and Gynecology, Franciscus Gasthuis and Vlietland, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bandell+ML%22">Bandell ML</searchLink>; Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bekker+MN%22">Bekker MN</searchLink>; Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wouters+MGAJ%22">Wouters MGAJ</searchLink>; Department of Obstetrics and Gynecology, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mijatovic+V%22">Mijatovic V</searchLink>; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Reproductive Medicine, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Franx+A%22">Franx A</searchLink>; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lambalk+CB%22">Lambalk CB</searchLink>; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Reproductive Medicine, Amsterdam University Medical Center location AMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Broekmans+FJM%22">Broekmans FJM</searchLink>; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands.; Centre for Reproductive Medicine, Dijklander Ziekenhuis, Purmerend, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Weerd+S%22">de Weerd S</searchLink>; Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gerards+JMH%22">Gerards JMH</searchLink>; Department of Obstetrics and Gynecology, Diakonessenhuis Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Baalman+JH%22">Baalman JH</searchLink>; Department of Obstetrics and Gynecology, Medisch Spectrum Twente, Enschede, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Disseldorp+J%22">van Disseldorp J</searchLink>; Department of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Langenveld+J%22">Langenveld J</searchLink>; Department of Obstetrics and Gynecology, Zuyderland MC, Heerlen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gunning+MN%22">Gunning MN</searchLink>; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Frederix+GWJ%22">Frederix GWJ</searchLink>; Department of Public Health, Julius Center Research Program Methodology, University Medical Centre Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Painter+RC%22">Painter RC</searchLink>; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands.; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fauser+BCJM%22">Fauser BCJM</searchLink>; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Laven+JSE%22">Laven JSE</searchLink>; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Rijn+BB%22">van Rijn BB</searchLink>; Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, the Netherlands.; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
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