Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
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| Title: | Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals. |
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| Authors: | Selvaraj MS; Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA.; Department of Medicine,, Harvard Medical School, Boston, MA , 02115, USA., Li X; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Li Z; Department of Biostatistics Harvard T.H. Chan School of Public Health,, Boston, MA, 02115, USA., Van Buren E; Department of Biostatistics Harvard T.H. Chan School of Public Health,, Boston, MA, 02115, USA., Haidermota S; Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA., Postupaka D; Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA., Hornsby W; Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, 78520, TX , USA., Damrauer SM; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Corporal Michael J. Crescenz Memorial Veterans Affairs Medical Center, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., de Las Fuentes L; Department of Medicine, Cardiovascular Division, Global Health Center, Institute for Public Health, and Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, , Houston, TX, USA., Duggirala R; Department of Health and Behavioral Sciences, College of Arts and Sciences,, Texas A&M University-San Antonio, San Antonio, TX, 78224, USA., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Graff M; Department of Epidemiology, UNC,, Chapel Hill, NC, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Hidalgo BA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Hou L; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Irvin R; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USA., Judy R; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kalyani RR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA., Kelly TN; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, 60612, IL, USA., Konigsberg IR; Department of Biomedical Informatics School of Medicine, University of Colorado, Aurora, CO, USA., Kral BG; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA., Kwee LC; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch National Heart, Lung, and Blood Institute,, Bethesda, MD, USA., Li C; Department of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Manichaikul AW; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Martin LW; Division of Cardiology, Department of Medicine, George Washington University, Washington DC, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine,, Baltimore, MD, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, , Houston, TX, USA., Naseri T; Naseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa.; International Health Institute, Brown University, Providence, RI, USA., North KE; Department of Epidemiology and Population Health Albert, Einstein College of Medicine, Bronx, 10461, NY, USA., O'Connell JR; Department of Medicine, University of Maryland School of Medicine,, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, 27157, NC, USA., Peyser PA; Department of Epidemiology, School of Public Healt, University of Michigan, Ann Arbor, MI, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai,, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Smith JA; Department of Epidemiology, School of Public Healt, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Tiwari H; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, 35294, AL, USA., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Viali S; Oceanian University of Medicine, Apia, Samoa.; School of Medicine, National University of Samoa, Apia, Samoa.; Dept of Chronic Disease Epidemiology School of Public Health, Yale University, New Haven, CT, USA., Wang Z; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai,, New York, NY, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, 02118, MA, USA., Zhao W; Department of Epidemiology, School of Public Healt, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Arnett DK; Provost, University of South Carolina, Columbia, 29208, SC, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, 78520, TX , USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, , Houston, TX, USA., Bowden DW; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, 27157, NC, USA., Carlson JC; Departments of Human Genetics and Biostatistics, School of Public Health,, University of Pittsburgh, Pittsburgh, PA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA., Fornage M; Brown Foundation Institute of Molecular Medicine McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, 7722, TX, USA., He J; Department of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Heard-Costa N; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kaplan RC; Department of Epidemiology, UNC,, Chapel Hill, NC, USA., Kardia SLR; Department of Epidemiology, School of Public Healt, University of Michigan, Ann Arbor, MI, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Lange LA; Department of Biomedical Informatics School of Medicine, University of Colorado, Aurora, CO, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai,, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Mitchell BD; Department of Medicine, University of Maryland School of Medicine,, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Rader DJ; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Medicine Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA., Gibbs R; Baylor College of Medicine Human Genome Sequencing Center, Houston, 77030, TX, USA., Gabriel S; Broad Institute, Cambridge, 02142, MA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina,. Inc., , San Diego, 92122, CA, USA., Dutcher SK; The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, 63110, MO, USA., Germer S; New York Genome Center, New York, 10013, NY, USA., Kim R; Psomagen, Inc. (formerly Macrogen USA), Rockville, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Lin X; Department of Biostatistics Harvard T.H. Chan School of Public Health,, Boston, MA, 02115, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, 02118, MA, USA. gpeloso@bu.edu., Natarajan P; Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA. pnatarajan@mgh.harvard.edu.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, , Cambridge, MA , 02141, USA. pnatarajan@mgh.harvard.edu.; Department of Medicine,, Harvard Medical School, Boston, MA , 02115, USA. pnatarajan@mgh.harvard.edu. |
| Corporate Authors: | NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium |
| Source: | Genome biology [Genome Biol] 2025 Sep 09; Vol. 26 (1), pp. 273. Date of Electronic Publication: 2025 Sep 09. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1474-760X |
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| DOI: | 10.1186/s13059-025-03698-0 |
