Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial.
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| Title: | Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial. |
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| Authors: | Ng ABCD; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Asif A; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Agarwal R; Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom., Panebianco V; Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy., Girometti R; Institute of Radiology, Department of Medicine, University of Udine, Udine, Italy.; Institute of Radiology, University Hospital S. Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy., Ghai S; Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto, Ontario, Canada.; University Health Network-Mount Sinai Hospital-Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Gómez-Gómez E; Urology Department Reina Sofia University Hospital, IMIBIC, Cordoba, Spain., Budäus L; Martini-Klinik Prostate Cancer Center, University Hospital-Hamburg-Eppendorf, Hamburg, Germany.; Martini-Klinik Prostate Cancer Center and Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Barrett T; Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Radtke JP; Department of Urology, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.; Department of Radiology, German Cancer Research Center, Heidelburg, Germany., Kesch C; Department of Urology, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany., De Cobelli F; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Pham T; Monash University, Melbourne, Australia., Taneja SS; New York University Grossman School of Medicine, New York., Hu JC; Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Hospital, New York., Tewari A; Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York., Rodríguez Cabello MÁ; Department of Urology, Hospital Universitario Sanitas La Moraleja, Madrid, Spain., Dias AB; Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto, Ontario, Canada.; University Health Network-Mount Sinai Hospital-Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Department of Radiology, Hospital Sírio-Libanês, São Paulo, Brazil., Mynderse LA; Mayo Clinic, Rochester, Minnesota., Borghi M; Centro de Urología, Buenos Aires, Argentina., Boesen L; Department of Urology and Urological Research, Herlev Gentofte University Hospital, Hellerup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Singh P; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Royal Free London NHS Foundation Trust, London, United Kingdom., Renard-Penna R; Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Paris, France.; Department of Radiology, Hôpital Pitié-Salpétrière, Paris, France., Leow JJ; Department of Urology, Tan Tock Seng Hospital, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Falkenbach F; Martini-Klinik Prostate Cancer Center, University Hospital-Hamburg-Eppendorf, Hamburg, Germany.; Martini-Klinik Prostate Cancer Center and Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pecoraro M; Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy., Giannarini G; Urology Unit, University Hospital S. Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy., Perlis N; Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Toronto, Ontario, Canada., López-Ruiz D; Radiology Department Reina Sofia University Hospital, IMIBIC, Cordoba, Spain., Kastner C; Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Schimmöller L; University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, Germany.; Department of Diagnostic, Interventional Radiology and Nuclear Medicine, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany., Rossiter M; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Nathan A; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Khetrapal P; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Chan VW; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom., Haider A; Department of Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Clarke CS; UCL Research Department of Primary Care and Population Health, University College London, London, United Kingdom., Punwani S; Centre for Medical Imaging, University College London, London, United Kingdom., Brew-Graves C; Centre for Medical Imaging, University College London, London, United Kingdom., Dickinson L; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Mitra A; Department of Clinical Oncology, UCLH NHS Foundation Trust, London, United Kingdom., Brembilla G; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Margolis DJA; Weill Cornell Medical College, New York, New York., Takwoingi Y; Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom.; NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, United Kingdom., Emberton M; Division of Surgery and Interventional Science, UCL, London, United Kingdom., Allen C; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Giganti F; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Moore CM; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Department of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Kasivisvanathan V; Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom.; Department of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom. |
| Corporate Authors: | PRIME Study Group Collaborators |
| Source: | JAMA [JAMA] 2025 Oct 07; Vol. 334 (13), pp. 1170-1179. |
| Publication Type: | Equivalence Trial; Journal Article; Multicenter Study |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.13722 |
