Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis.
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| Title: | Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis. |
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| Authors: | Shi H; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Wang X; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Sloas C; Carisma Therapeutics Inc., Philadelphia, PA 19104, USA., Gerlach B; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Yurdagul A Jr; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Moore MP; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Jung EJ; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Mirshahi F; Divsion of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Ronzoni L; Precision Medicine Lab, Biological Resource Center, Department of Transfusion Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano 20122, Italy., Sanyal AJ; Divsion of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Valenti L; Precision Medicine Lab, Biological Resource Center, Department of Transfusion Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.; Department of Pathophysiology and Transplantation, Universitàdegli Studi di Milano, Milan 20122, Italy., Lin CS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Montgomery J; Carisma Therapeutics Inc., Philadelphia, PA 19104, USA., Zinker B; Carisma Therapeutics Inc., Philadelphia, PA 19104, USA., Klichinsky M; Carisma Therapeutics Inc., Philadelphia, PA 19104, USA., Tabas I; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Sep 10; Vol. 17 (815), pp. eadv2106. Date of Electronic Publication: 2025 Sep 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adv2106 |
