Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy.

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Title: Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy.
Authors: Hata R; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Funakoshi S; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: s.funakoshi@cira.kyoto-u.ac.jp., Makiyama T; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Kato T; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Narita M; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Matsumura Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Hirohata R; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Naka Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan., Ida K; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan., Ito H; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan., Yoshizawa A; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan; Department of Diagnostic Pathology, Nara Medical University, Nara, Japan., Nannya Y; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Hematology and Oncology, Tokyo University Medical Research Institute, Tokyo, Japan., Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Sakyo-ku, Kyoto, Japan., Ono K; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Kimura T; Department of Cardiology, Hirakata Kosai Hospital, Hirakata-city, Osaka, Japan., Yoshida Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: yoshinor@cira.kyoto-u.ac.jp.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2025 Oct; Vol. 10 (10), pp. 101363. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-302X
DOI:10.1016/j.jacbts.2025.101363