Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy.
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| Title: | Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy. |
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| Authors: | Hata R; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Funakoshi S; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: s.funakoshi@cira.kyoto-u.ac.jp., Makiyama T; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Kato T; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Narita M; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Matsumura Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Hirohata R; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan., Naka Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan., Ida K; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan., Ito H; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan., Yoshizawa A; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan; Department of Diagnostic Pathology, Nara Medical University, Nara, Japan., Nannya Y; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Hematology and Oncology, Tokyo University Medical Research Institute, Tokyo, Japan., Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Sakyo-ku, Kyoto, Japan., Ono K; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan., Kimura T; Department of Cardiology, Hirakata Kosai Hospital, Hirakata-city, Osaka, Japan., Yoshida Y; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: yoshinor@cira.kyoto-u.ac.jp. |
| Source: | JACC. Basic to translational science [JACC Basic Transl Sci] 2025 Oct; Vol. 10 (10), pp. 101363. Date of Electronic Publication: 2025 Sep 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40934809 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hata+R%22">Hata R</searchLink>; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Funakoshi+S%22">Funakoshi S</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: s.funakoshi@cira.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Makiyama+T%22">Makiyama T</searchLink>; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Narita+M%22">Narita M</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumura+Y%22">Matsumura Y</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hirohata+R%22">Hirohata R</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Naka+Y%22">Naka Y</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ida+K%22">Ida K</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+H%22">Ito H</searchLink>; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshizawa+A%22">Yoshizawa A</searchLink>; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan; Department of Diagnostic Pathology, Nara Medical University, Nara, Japan.<br /><searchLink fieldCode="AU" term="%22Nannya+Y%22">Nannya Y</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Department of Hematology and Oncology, Tokyo University Medical Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Haga+H%22">Haga H</searchLink>; Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ono+K%22">Ono K</searchLink>; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kimura+T%22">Kimura T</searchLink>; Department of Cardiology, Hirakata Kosai Hospital, Hirakata-city, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+Y%22">Yoshida Y</searchLink>; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; Takeda-CiRA Joint Program, Kanagawa, Japan. Electronic address: yoshinor@cira.kyoto-u.ac.jp. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2025 Oct; Vol. 10 (10), pp. 101363. <i>Date of Electronic Publication: </i>2025 Sep 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+on+behalf+of+the+American+College+of+Cardiology+Foundation%22">Elsevier on behalf of the American College of Cardiology Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101677259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2452-302X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222452302X%22">2452302X </searchLink><i>NLM ISO Abbreviation: </i>JACC Basic Transl Sci <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40934809 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jacbts.2025.101363 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 101363 Titles: – TitleFull: Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hata R – PersonEntity: Name: NameFull: Funakoshi S – PersonEntity: Name: NameFull: Makiyama T – PersonEntity: Name: NameFull: Kato T – PersonEntity: Name: NameFull: Narita M – PersonEntity: Name: NameFull: Matsumura Y – PersonEntity: Name: NameFull: Hirohata R – PersonEntity: Name: NameFull: Naka Y – PersonEntity: Name: NameFull: Ida K – PersonEntity: Name: NameFull: Ito H – PersonEntity: Name: NameFull: Yoshizawa A – PersonEntity: Name: NameFull: Nannya Y – PersonEntity: Name: NameFull: Haga H – PersonEntity: Name: NameFull: Ogawa S – PersonEntity: Name: NameFull: Ono K – PersonEntity: Name: NameFull: Kimura T – PersonEntity: Name: NameFull: Yoshida Y IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: 2025 Oct Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2452-302X Numbering: – Type: volume Value: 10 – Type: issue Value: 10 Titles: – TitleFull: JACC. Basic to translational science Type: main |
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