Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.

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Title: Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.
Authors: Rao VS; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut., Cox ZL; Department of Pharmacy Practice, Lipscomb University College of Pharmacy, Nashville, Tennessee.; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Ivey-Miranda JB; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Hospital de Cardiologia, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Moreno-Villagomez J; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Ramos-Mastache D; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Maulion C; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut., Bellumkonda L; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut., Turner J; Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut., Wilson FP; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Clinical and Translational Research Accelerator, Yale University School of Medicine, New Haven, Connecticut., Shilpak MG; Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California., Estrella MM; Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California., Welling P; Departments of Medicine and Physiology, John Hopkins School of Medicine, Baltimore, Maryland., Wilcox CS; Division of Nephrology and Hypertension Center, Georgetown University, Washington, DC., Ellison DH; Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon., Forbush B; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut., Testani JM; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Source: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2026 Mar 01; Vol. 37 (3), pp. 533-544. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-3450 (Electronic) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE; In Process
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  Data: Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.
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  Data: <searchLink fieldCode="AU" term="%22Rao+VS%22">Rao VS</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Cox+ZL%22">Cox ZL</searchLink>; Department of Pharmacy Practice, Lipscomb University College of Pharmacy, Nashville, Tennessee.; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Ivey-Miranda+JB%22">Ivey-Miranda JB</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Hospital de Cardiologia, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Moreno-Villagomez+J%22">Moreno-Villagomez J</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Ramos-Mastache+D%22">Ramos-Mastache D</searchLink>; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Maulion+C%22">Maulion C</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Bellumkonda+L%22">Bellumkonda L</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Turner+J%22">Turner J</searchLink>; Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Wilson+FP%22">Wilson FP</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.; Clinical and Translational Research Accelerator, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Shilpak+MG%22">Shilpak MG</searchLink>; Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Estrella+MM%22">Estrella MM</searchLink>; Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Welling+P%22">Welling P</searchLink>; Departments of Medicine and Physiology, John Hopkins School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Wilcox+CS%22">Wilcox CS</searchLink>; Division of Nephrology and Hypertension Center, Georgetown University, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Ellison+DH%22">Ellison DH</searchLink>; Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Forbush+B%22">Forbush B</searchLink>; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Testani+JM%22">Testani JM</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
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  Data: <searchLink fieldCode="JN" term="%229013836%22">Journal of the American Society of Nephrology : JASN</searchLink> [J Am Soc Nephrol] 2026 Mar 01; Vol. 37 (3), pp. 533-544. <i>Date of Electronic Publication: </i>2025 Sep 12.
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      – TitleFull: Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.
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