Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
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| Title: | Genome-wide association study provides novel insight into the genetic architecture of severe obesity. |
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| Authors: | Krishnan M; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America., Anwar MY; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Justice AE; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Chittoor G; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Chen HH; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Roshani R; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Scartozzi A; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Dickerson RR; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America., Smit RAJ; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Hovedstaden, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Chami N; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Hadad BS; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Parra EJ; Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada., Cruz M; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Wilson PWF; Atlanta VA Health Care System, Decatur, Georgia, United States of America.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Zhang X; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Linchangco GV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Faul JD; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Weir DR; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Highland HM; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Young KL; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Qi B; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Wang Y; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, United States of America., Haiman C; Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America., Cheng I; Cancer Prevention Institute of California, University of Southern California, Fremont, California, United States of America., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Buyske S; Department of Statistics, Rutgers University, New Brunswick, New Jersey, United States of America., McCormick JB; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Fisher-Hoch SP; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Lona-Durazo F; Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Montréal Heart Institute, Montréal, Québec, Canada., Peralta J; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Gomez-Zamudio J; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, Virginia, United States of America., Ferrier KR; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Lange EM; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Gignoux CR; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Kenny EE; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Wojcik GL; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Cho K; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Gaziano MJ; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Djousse L; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Liu S; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America., Vaidya D; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Josyula NS; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Bauer CR; Department of Human Medical Genetics and Genomics, University of Colorado Denver, Denver, Colorado, United States of America., Zhao W; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Walker RW; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Lange LA; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Meyer MC; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Yanek LR; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America., Lee M; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Hovedstaden, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Gordon-Larsen P; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Nutrition, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Below JE; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., North KE; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Graff M; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America. |
| Source: | PLoS genetics [PLoS Genet] 2025 Sep 12; Vol. 21 (9), pp. e1011842. Date of Electronic Publication: 2025 Sep 12 (Print Publication: 2025). |
| Publication Type: | Journal Article; Meta-Analysis; Review |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7404 |
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| DOI: | 10.1371/journal.pgen.1011842 |
