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Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

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Title: Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
Authors: Krishnan M; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America., Anwar MY; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Justice AE; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Chittoor G; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Chen HH; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Roshani R; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Scartozzi A; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Dickerson RR; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America., Smit RAJ; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Hovedstaden, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Chami N; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Hadad BS; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Parra EJ; Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada., Cruz M; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Wilson PWF; Atlanta VA Health Care System, Decatur, Georgia, United States of America.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Zhang X; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Linchangco GV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Faul JD; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Weir DR; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Highland HM; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Young KL; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Qi B; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Wang Y; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, United States of America., Haiman C; Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America., Cheng I; Cancer Prevention Institute of California, University of Southern California, Fremont, California, United States of America., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Buyske S; Department of Statistics, Rutgers University, New Brunswick, New Jersey, United States of America., McCormick JB; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Fisher-Hoch SP; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Lona-Durazo F; Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Montréal Heart Institute, Montréal, Québec, Canada., Peralta J; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Gomez-Zamudio J; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, Virginia, United States of America., Ferrier KR; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Lange EM; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Gignoux CR; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Kenny EE; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Wojcik GL; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Cho K; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Gaziano MJ; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Djousse L; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Liu S; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America., Vaidya D; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Josyula NS; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America., Bauer CR; Department of Human Medical Genetics and Genomics, University of Colorado Denver, Denver, Colorado, United States of America., Zhao W; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Walker RW; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America., Lange LA; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Meyer MC; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Yanek LR; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America., Lee M; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Hovedstaden, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Gordon-Larsen P; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Nutrition, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Below JE; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., North KE; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America., Graff M; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.
Source: PLoS genetics [PLoS Genet] 2025 Sep 12; Vol. 21 (9), pp. e1011842. Date of Electronic Publication: 2025 Sep 12 (Print Publication: 2025).
Publication Type: Journal Article; Meta-Analysis; Review
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
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  Data: Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
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  Data: <searchLink fieldCode="AU" term="%22Krishnan+M%22">Krishnan M</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Anwar+MY%22">Anwar MY</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Justice+AE%22">Justice AE</searchLink>; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Chittoor+G%22">Chittoor G</searchLink>; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Roshani+R%22">Roshani R</searchLink>; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Scartozzi+A%22">Scartozzi A</searchLink>; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Dickerson+RR%22">Dickerson RR</searchLink>; Biobehavioral Health Department, The Pennsylvania State University, University Park, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Smit+RAJ%22">Smit RAJ</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; 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Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cruz+M%22">Cruz M</searchLink>; Unidad de Investigación Medica en Bioquímica Hospital de Especialidades, Centro Medico Siglo XXI, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Hui+Q%22">Hui Q</searchLink>; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; Atlanta VA Health Care System, Decatur, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Wilson+PWF%22">Wilson PWF</searchLink>; Atlanta VA Health Care System, Decatur, Georgia, United States of America.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Sun+YV%22">Sun YV</searchLink>; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.; 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Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America.<br /><searchLink fieldCode="AU" term="%22Bielak+LF%22">Bielak LF</searchLink>; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.<br /><searchLink fieldCode="AU" term="%22Highland+HM%22">Highland HM</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Young+KL%22">Young KL</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Qi+B%22">Qi B</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Haiman+C%22">Haiman C</searchLink>; Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Cheng+I%22">Cheng I</searchLink>; Cancer Prevention Institute of California, University of Southern California, Fremont, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Kooperberg+C%22">Kooperberg C</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Buyske+S%22">Buyske S</searchLink>; Department of Statistics, Rutgers University, New Brunswick, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22McCormick+JB%22">McCormick JB</searchLink>; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Fisher-Hoch+SP%22">Fisher-Hoch SP</searchLink>; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Lona-Durazo+F%22">Lona-Durazo F</searchLink>; Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; 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Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Djousse+L%22">Djousse L</searchLink>; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Vaidya+D%22">Vaidya D</searchLink>; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22de+Mutsert+R%22">de Mutsert R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Josyula+NS%22">Josyula NS</searchLink>; Population Health Sciences, Geisinger, Danville, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Bauer+CR%22">Bauer CR</searchLink>; Department of Human Medical Genetics and Genomics, University of Colorado Denver, Denver, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America.<br /><searchLink fieldCode="AU" term="%22Walker+RW%22">Walker RW</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.; Survey Research Center, University of Michigan Institute for Social Research, Ann Arbor, Michigan, United States of America.<br /><searchLink fieldCode="AU" term="%22Lange+LA%22">Lange LA</searchLink>; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Meyer+MC%22">Meyer MC</searchLink>; Division of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Liu+CT%22">Liu CT</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Yanek+LR%22">Yanek LR</searchLink>; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Lee+M%22">Lee M</searchLink>; The School of Public Health, University of Texas at Brownsville, Brownsville, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Hovedstaden, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Gordon-Larsen+P%22">Gordon-Larsen P</searchLink>; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Nutrition, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Below+JE%22">Below JE</searchLink>; Division of Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22North+KE%22">North KE</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Graff+M%22">Graff M</searchLink>; Department of Epidemiology University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101239074%22">PLoS genetics</searchLink> [PLoS Genet] 2025 Sep 12; Vol. 21 (9), pp. e1011842. <i>Date of Electronic Publication: </i>2025 Sep 12 (<i>Print Publication: </i>2025).
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            – D: 12
              M: 09
              Text: 2025 Sep 12
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1553-7404
          Numbering:
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              Value: 21
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: PLoS genetics
              Type: main
ResultId 1