Catheter-based left atrial appendage CLOSURE in patients with atrial fibrillation at high risk of stroke and bleeding as compared to best medical therapy: Rationale and design of the prospective randomized CLOSURE-AF trial.

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Title: Catheter-based left atrial appendage CLOSURE in patients with atrial fibrillation at high risk of stroke and bleeding as compared to best medical therapy: Rationale and design of the prospective randomized CLOSURE-AF trial.
Authors: Landmesser U; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany. Electronic address: Ulf.Landmesser@dhzc-charite.de., Skurk C; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany., Kirchhof P; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK., Lewalter T; Department of Cardiology and Intensive Unit Care, Hospital Munich South, Peter Osypka Heart Center, Munich, Germany., Hartung J; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany., Rroku A; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany., Pieske B; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Rostock, Germany., Brachmann J; Department of Cardiology, Sana-Klinikum Coburg, Coburg, Germany., Akin I; Department of Cardiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Jacobshagen C; Department of Cardiology, Intensive Care Medicine and Angiology, Vincentius-Diakonissen Hospital, Karlsruhe, Germany., Meder B; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Zeiher A; Department of Medicine III, Goethe University, Frankfurt, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Rhein Main Frankfurt Germany., Anker SD; German Center for Cardiovascular Research (DZHK), Berlin, Germany; Institute of Health Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité - Universitätsmedizin, Berlin, Germany., Thiele H; Heart Center at Leipzig University, Department of Internal Medicine/Cardiology, Leipzig, Germany., Blankenberg S; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany., Massberg S; Department of Medicine I, LMU University Hospital, Ludwig Maximillian University of Munich, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany., Schunkert H; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany; Department of Cardiovascular Diseases, German Heart Centre, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany., Frey N; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Joost A; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany; University Heart Center Lübeck, Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), Lübeck, Germany., Bergmann M; Department of Cardiology, Asklepios Klinik Altona, Hamburg, Germany., Haeusler KG; Department of Neurology, Universitätsklinikum Ulm, Ulm, Germany., Endres M; German Center for Cardiovascular Research (DZHK), Berlin, Germany; Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany., Wegscheider K; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boldt LH; German Center for Cardiovascular Research (DZHK), Berlin, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Charité-University Medicine Berlin, Campus Virchow, Berlin, Germany., Eitel I; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany; University Heart Center Lübeck, Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), Lübeck, Germany. Electronic address: ingo.eitel@uskh.de.
Source: American heart journal [Am Heart J] 2026 Feb; Vol. 292, pp. 107273. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-6744
DOI:10.1016/j.ahj.2025.09.005