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Combined agonism of nutrient receptors GPR40 and GPR119 with K-757 and K-833 results in weight loss and blood pressure reductions in obese subjects without type 2 diabetes mellitus.

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Title: Combined agonism of nutrient receptors GPR40 and GPR119 with K-757 and K-833 results in weight loss and blood pressure reductions in obese subjects without type 2 diabetes mellitus.
Authors: Crutchlow M; Kallyope, Inc., New York, New York, USA., Liu J; Kallyope, Inc., New York, New York, USA., Romero C; Headlands Research, Brownsville, Texas, USA., Watkins E; ProSciento, Chula Vista, California, USA., Zhang H; Kallyope, Inc., New York, New York, USA., Arreglado A; Kallyope, Inc., New York, New York, USA., Vance A; Kallyope, Inc., New York, New York, USA., Boisvert D; Kallyope, Inc., New York, New York, USA., Terracina G; Kallyope, Inc., New York, New York, USA., Chan B; Kallyope, Inc., New York, New York, USA., Consolati MJ; Kallyope, Inc., New York, New York, USA., Poterewicz G; Kallyope, Inc., New York, New York, USA., Talaty JE; BCH Research Solutions, LLC, Conshohocken, Pennsylvania, USA., Lauring B; Kallyope, Inc., New York, New York, USA.
Source: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7198-7209. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Combined agonism of nutrient receptors GPR40 and GPR119 with K-757 and K-833 results in weight loss and blood pressure reductions in obese subjects without type 2 diabetes mellitus.
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  Data: <searchLink fieldCode="AU" term="%22Crutchlow+M%22">Crutchlow M</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Romero+C%22">Romero C</searchLink>; Headlands Research, Brownsville, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Watkins+E%22">Watkins E</searchLink>; ProSciento, Chula Vista, California, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Arreglado+A%22">Arreglado A</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Vance+A%22">Vance A</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Boisvert+D%22">Boisvert D</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Terracina+G%22">Terracina G</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chan+B%22">Chan B</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Consolati+MJ%22">Consolati MJ</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Poterewicz+G%22">Poterewicz G</searchLink>; Kallyope, Inc., New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Talaty+JE%22">Talaty JE</searchLink>; BCH Research Solutions, LLC, Conshohocken, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lauring+B%22">Lauring B</searchLink>; Kallyope, Inc., New York, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22100883645%22">Diabetes, obesity & metabolism</searchLink> [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7198-7209. <i>Date of Electronic Publication: </i>2025 Sep 15.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100883645 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1463-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214628902%22">14628902 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes Obes Metab <i>Subsets: </i>MEDLINE
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        Value: 10.1111/dom.70120
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      – Code: eng
        Text: English
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      – TitleFull: Combined agonism of nutrient receptors GPR40 and GPR119 with K-757 and K-833 results in weight loss and blood pressure reductions in obese subjects without type 2 diabetes mellitus.
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            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
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