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Tiprelestat for treatment of hospitalized COVID-19: results of the double-blind randomized placebo-controlled COMCOVID trial.

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Title: Tiprelestat for treatment of hospitalized COVID-19: results of the double-blind randomized placebo-controlled COMCOVID trial.
Authors: Bergs I; Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. ibergs@ukaachen.de., Budweiser S; Department of Internal Medicine III, RoMed Klinikum Rosenheim, Rosenheim, Germany., Henneicke-von Zepelin HH; tiakis Biotech AG, Kiel, Germany., Kelm H; Department of Pneumology, Ruppin Hospital, Neuruppin, Germany., Bollmann T; Department of Pneumology, Helios Hospital, Stralsund, Germany., Tebbe JJ; Department of Gastroenterology and Infectiology, Hospital Lippe, Medical School and University Medical Center OWL, Bielefeld University, Bielefeld, Germany., Sorichter S; Department of Pneumology and Respiratory Medicine, St. Josefskrankenhaus, Freiburg i.B., Germany., Lüth S; Department of Internal Medicine II, University Hospital, Brandenburg an der Havel, Germany., Walterspacher S; Department Department of Pneumology, Medical Clinic, Hospital of Konstanz, Constance, Germany, and Witten/Herdecke University, Witten, Germany., Wege H; Department of General Internal Medicine, Oncology/Haematology, Gastroenterology and Infectiology, Hospital Esslingen, Esslingen, Germany., Wiedow O; tiakis Biotech AG, Kiel, Germany., Dreher M; Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.
Source: Advances in therapy [Adv Ther] 2025 Nov; Vol. 42 (11), pp. 5683-5695. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tiprelestat for treatment of hospitalized COVID-19: results of the double-blind randomized placebo-controlled COMCOVID trial.
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  Data: <searchLink fieldCode="AU" term="%22Bergs+I%22">Bergs I</searchLink>; Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. ibergs@ukaachen.de.<br /><searchLink fieldCode="AU" term="%22Budweiser+S%22">Budweiser S</searchLink>; Department of Internal Medicine III, RoMed Klinikum Rosenheim, Rosenheim, Germany.<br /><searchLink fieldCode="AU" term="%22Henneicke-von+Zepelin+HH%22">Henneicke-von Zepelin HH</searchLink>; tiakis Biotech AG, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Kelm+H%22">Kelm H</searchLink>; Department of Pneumology, Ruppin Hospital, Neuruppin, Germany.<br /><searchLink fieldCode="AU" term="%22Bollmann+T%22">Bollmann T</searchLink>; Department of Pneumology, Helios Hospital, Stralsund, Germany.<br /><searchLink fieldCode="AU" term="%22Tebbe+JJ%22">Tebbe JJ</searchLink>; Department of Gastroenterology and Infectiology, Hospital Lippe, Medical School and University Medical Center OWL, Bielefeld University, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Sorichter+S%22">Sorichter S</searchLink>; Department of Pneumology and Respiratory Medicine, St. Josefskrankenhaus, Freiburg i.B., Germany.<br /><searchLink fieldCode="AU" term="%22Lüth+S%22">Lüth S</searchLink>; Department of Internal Medicine II, University Hospital, Brandenburg an der Havel, Germany.<br /><searchLink fieldCode="AU" term="%22Walterspacher+S%22">Walterspacher S</searchLink>; Department Department of Pneumology, Medical Clinic, Hospital of Konstanz, Constance, Germany, and Witten/Herdecke University, Witten, Germany.<br /><searchLink fieldCode="AU" term="%22Wege+H%22">Wege H</searchLink>; Department of General Internal Medicine, Oncology/Haematology, Gastroenterology and Infectiology, Hospital Esslingen, Esslingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wiedow+O%22">Wiedow O</searchLink>; tiakis Biotech AG, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Dreher+M%22">Dreher M</searchLink>; Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.
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  Data: <searchLink fieldCode="JN" term="%228611864%22">Advances in therapy</searchLink> [Adv Ther] 2025 Nov; Vol. 42 (11), pp. 5683-5695. <i>Date of Electronic Publication: </i>2025 Sep 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Health+Communications+Inc%22">Health Communications Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8611864 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1865-8652 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220741238X%22">0741238X </searchLink><i>NLM ISO Abbreviation: </i>Adv Ther <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov
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