The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways.

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Title: The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways.
Authors: Nagai E; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Ori D; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Kano N; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Ikegawa M; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan., Kobiyama K; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Ishii KJ; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Kawasaki T; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan., Kawai T; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Life Science Collaboration Center (LiSCo), Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Medilux Research Center, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.
Source: International immunology [Int Immunol] 2026 Feb 09; Vol. 38 (2), pp. 118-133.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: [Oxford University Press Country of Publication: England NLM ID: 8916182 Publication Model: Print Cited Medium: Internet ISSN: 1460-2377 (Electronic) Linking ISSN: 09538178 NLM ISO Abbreviation: Int Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2377
DOI:10.1093/intimm/dxaf054