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The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways.

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Title: The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways.
Authors: Nagai E; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Ori D; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Kano N; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan., Ikegawa M; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan., Kobiyama K; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Ishii KJ; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Kawasaki T; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan., Kawai T; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Life Science Collaboration Center (LiSCo), Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Medilux Research Center, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.
Source: International immunology [Int Immunol] 2026 Feb 09; Vol. 38 (2), pp. 118-133.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: [Oxford University Press Country of Publication: England NLM ID: 8916182 Publication Model: Print Cited Medium: Internet ISSN: 1460-2377 (Electronic) Linking ISSN: 09538178 NLM ISO Abbreviation: Int Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways.
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  Data: <searchLink fieldCode="AU" term="%22Nagai+E%22">Nagai E</searchLink>; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.<br /><searchLink fieldCode="AU" term="%22Ori+D%22">Ori D</searchLink>; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.<br /><searchLink fieldCode="AU" term="%22Kano+N%22">Kano N</searchLink>; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.<br /><searchLink fieldCode="AU" term="%22Ikegawa+M%22">Ikegawa M</searchLink>; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan.<br /><searchLink fieldCode="AU" term="%22Kobiyama+K%22">Kobiyama K</searchLink>; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Ishii+KJ%22">Ishii KJ</searchLink>; Division of Vaccine Science, Department of Microbiology and Immunology, The University of Tokyo, Tokyo 108-8639, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Kawasaki+T%22">Kawasaki T</searchLink>; Immune Dynamics in Viral Infections, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+T%22">Kawai T</searchLink>; Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Life Science Collaboration Center (LiSCo), Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.; Medilux Research Center, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Japan.
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  Data: <searchLink fieldCode="JN" term="%228916182%22">International immunology</searchLink> [Int Immunol] 2026 Feb 09; Vol. 38 (2), pp. 118-133.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22[Oxford+University+Press%22">[Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8916182 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2377 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209538178%22">09538178 </searchLink><i>NLM ISO Abbreviation: </i>Int Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/intimm/dxaf054
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              Text: 2026 Feb 09
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              Y: 2026
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