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Bioavailability enhancement and neuropharmacological effects of Dauricine under intranasal administration to improve cognitive impairment via PI3K/AKT/mTOR pathway.

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Title: Bioavailability enhancement and neuropharmacological effects of Dauricine under intranasal administration to improve cognitive impairment via PI3K/AKT/mTOR pathway.
Authors: Xie R; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Liu Z; Department of Chemistry & the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China., Zheng J; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Tan Q; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Wu H; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Liang Y; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. liangyong@gzucm.edu.cn.; Department of Chemistry & the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China. liangyong@gzucm.edu.cn.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 May; Vol. 16 (5), pp. 1607-1628. Date of Electronic Publication: 2025 Sep 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2190-3948
DOI:10.1007/s13346-025-01975-w