7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.

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Title: 7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.
Authors: Tian Z; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Tan TT; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Hu YW; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Yao JT; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Kang XT; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Zhou JY; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China., Jia DX; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China., Li QL; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China., Liang RJ; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China., Zhao LM; Department of Pathology and Pathophysiology, Suzhou Medical College of Soochow University, Suzhou 215123, China., Zhu H; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China. Electronic address: daitutu990201@163.com., Zhao J; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China. Electronic address: zhaojinghmu@163.com., Hang PZ; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China. Electronic address: hangpengzhou@163.com.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Sep 22; Vol. 505, pp. 117578. Date of Electronic Publication: 2025 Sep 22.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-0333
DOI:10.1016/j.taap.2025.117578