Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.
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| Title: | Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program. |
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| Authors: | Sarnowski C; Department of Epidemiology, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Chloe.Sarnowski@uth.tmc.edu., Zhang Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Ammous F; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Shade LMP; Department of Biostatistics, University of Kentucky, Lexington, KY, USA., DiCorpo D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jian X; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC, USA., Austin TR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Beiser A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Bis JC; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Blangero J; Division of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Boerwinkle E; Department of Epidemiology, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Bressler J; Department of Epidemiology, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Curran JE; Division of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., DeCarli CS; Department of Neurology, University of California, Davis, CA, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, QC, Canada., Fardo DW; Department of Biostatistics, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Florez JC; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gabriel S; Genomics Platform, Broad Institute, Cambridge, MA, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Glahn DC; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA., Gupta N; Genomics Platform, Broad Institute, Cambridge, MA, USA., González HM; Department of Neurosciences and the Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego, San Diego, CA, USA., González KA; Department of Neurosciences and the Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego, San Diego, CA, USA., Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hayden KM; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Hidalgo B; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Huerta-Chagoya A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hughes TM; Departments of Internal Medicine and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kooperberg CL; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Mandla R; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Mathias RA; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Morris AP; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Division of Musculoskeletal and Dermatological Sciences, Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Nasrallah IM; Department of Radiology, Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Nyquist P; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Qi Q; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Raffield LM; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rayner NW; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sevilla-Gonzalez MDR; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Smith AV; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Smith K; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Snively BM; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Sofer T; Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Suzuki K; Division of Musculoskeletal and Dermatological Sciences, Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Taylor HJ; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Udler MS; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina, Inc., San Diego, CA, USA., Wassertheil-Smoller S; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Wood AC; USDA/ARS Children Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA., Yanek LR; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China., Manning AK; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Meigs JB; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Fornage M; Department of Epidemiology, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, Houston, TX, USA., Seshadri S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Morrison AC; Department of Epidemiology, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
| Corporate Authors: | T2DGGI consortium, MAGIC consortium, TOPMed Diabetes working group, and the TOPMed Neurocognitive working group |
| Source: | Communications biology [Commun Biol] 2025 Sep 24; Vol. 8 (1), pp. 1352. Date of Electronic Publication: 2025 Sep 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-025-08674-9 |
