Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.

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Title: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.
Authors: Colbert SMC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu., Monson ET; Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA., Andreassen OA; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT Centre, University of Oslo, Oslo, Norway., Ayinde OO; Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria., Barr PB; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; VA New York Harbor Healthcare System, New York, NY, USA.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Bejan CA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Ceja Z; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Coon H; Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA., DiBlasi E; Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA., Edenberg HJ; Department of Medical & Molecular Genetics, Indiana University, Bloomington, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Bloomington, IN, USA., Gelernter J; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, VA CT Healthcare System, West Haven, CT, USA., Hatoum A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Izotova A; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Kaufman EA; Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA., Kranzler HR; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA., Koromina M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lehto K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Myung W; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seongnam, South Korea., Nurnberger JI Jr; Department of Medical & Molecular Genetics, Indiana University, Bloomington, IN, USA.; Department of Psychiatry, Indiana University School of Medicine, Bloomington, IN, USA., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy.; Oasi Research Institute-IRCCS, Troina, Italy., Smoller JW; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Stein MB; Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, USA., Zai CC; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Erlangsen A; Center of Mental Health Research, Australian National University, Canberra, ACT, Australia.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Danish Research Institute for Suicide Prevention, Mental Health Centre Copenhagen, Copenhagen, Denmark., Gaine M; The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET), College of Pharmacy, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA., Martorell L; Research department, Hospital Universitari Institut Pere Mata, IISPV-CERCA, Reus, Spain.; Psychiatry Unit, Universitat Rovira i Virgili, Reus, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain., Sud R; Center for Brain and Mind, Department of Psychiatry, NIMHANS, Bangalore, India.; Molecular Genetics Laboratory, Department of Psychiatry, NIMHANS, Bangalore, India., Toma C; Centre for Molecular Biology Severo Ochoa (CBMSO), The Spanish National Research Council (CSIC) & Autonomous University of Madrid, Madrid, Spain.; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Clinical Medicine, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia., Bigdeli TB; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; VA New York Harbor Healthcare System, New York, NY, USA.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Kimbrel NA; Durham VA Health Care System, Durham, NC, USA.; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham, NC, USA.; VISN 6 Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., Ruderfer D; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Docherty AR; Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA.; Huntsman Mental Health Institute, Salt Lake City, UT, USA.; Clinical and Translational Science Institute & the Center for Genomic Medicine, University of Utah, Salt Lake City, UT, USA., Mann JJ; Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA., Mullins N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.
Corporate Authors: Psychiatric Genomics Consortium Suicide Working Group
Source: Molecular psychiatry [Mol Psychiatry] 2025 Dec; Vol. 30 (12), pp. 6144-6154. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03271-y