Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing.
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| Title: | Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. |
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| Authors: | Liu Y; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Avathan Veettil AK; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Gasper R; Crystallography and Biophysics Unit, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Jiang M; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Wagner L; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Hastürk O; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Wu P; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, Germany. peng.wu@mpi-dortmund.mpg.de.; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany. peng.wu@mpi-dortmund.mpg.de.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany. peng.wu@mpi-dortmund.mpg.de. |
| Source: | Nature communications [Nat Commun] 2025 Sep 26; Vol. 16 (1), pp. 8531. Date of Electronic Publication: 2025 Sep 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64291-4 |
