YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis.

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Title: YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis.
Authors: Wu YC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Hung TH; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan., Wang WT; Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Kuo MW; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan., Liang YJ; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan., Kuo YR; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Hou MF; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Lai CS; Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Yu AL; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan.; Chang Gung University, #15, Wenhua 1st Rd, Guishan Dist, Taoyuan, 333, Taiwan.; Department of Pediatrics, University of California in San Diego, San Diego, CA, 92103, USA., Yu J; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan. johnyu@gate.sinica.edu.tw.; Chang Gung University, #15, Wenhua 1st Rd, Guishan Dist, Taoyuan, 333, Taiwan. johnyu@gate.sinica.edu.tw.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2025 Sep 26; Vol. 31 (1), pp. 291. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1528-3658
DOI:10.1186/s10020-025-01347-7