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Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome.

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Title: Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome.
Authors: Edwards NC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.; Department of Neuroscience, Columbia University, New York City, New York, USA., Lao PJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Alshikho MJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Ericsson OM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Rizvi B; Department of Neurobiology & Behavior, University of California, Irvine, California, USA., Petersen ME; University of North Texas Health Science Center, Fort Worth, Texas, USA., O'Bryant S; University of North Texas Health Science Center, Fort Worth, Texas, USA., Flores-Aguilar L; Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, University of California, Irvine, California, USA., Simoes S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Mapstone M; Department of Neurology, University of California, Irvine, California, USA., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Janelidze S; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden., Hansson O; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Lee JH; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Lai F; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Rosas HD; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Radiology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, UK., Lott IT; Department of Pediatrics and Neurology, School of Medicine, University of California, Irvine, California, USA., Yassa MA; Department of Neurobiology & Behavior, University of California, Irvine, California, USA.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Wilcock DM; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, University of California, Irvine, California, USA., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.
Corporate Authors: Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70726.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Edwards+NC%22">Edwards NC</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.; Department of Neuroscience, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lao+PJ%22">Lao PJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Alshikho+MJ%22">Alshikho MJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ericsson+OM%22">Ericsson OM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rizvi+B%22">Rizvi B</searchLink>; Department of Neurobiology & Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+ME%22">Petersen ME</searchLink>; University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22O'Bryant+S%22">O'Bryant S</searchLink>; University of North Texas Health Science Center, Fort Worth, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Aguilar+L%22">Flores-Aguilar L</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Simoes+S%22">Simoes S</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Janelidze+S%22">Janelidze S</searchLink>; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Hansson+O%22">Hansson O</searchLink>; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Radiology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics and Neurology, School of Medicine, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Yassa+MA%22">Yassa MA</searchLink>; Department of Neurobiology & Behavior, University of California, Irvine, California, USA.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez+J%22">Gutierrez J</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wilcock+DM%22">Wilcock DM</searchLink>; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer's+Biomarkers+Consortium–Down+Syndrome+%28ABC‐DS%29+Investigators%22">Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70726.
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