Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties.
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| Title: | Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties. |
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| Authors: | Aaen KH; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Testa MF; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Nilsen J; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Tarantino R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Canepari C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Benedusi M; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy., Benjakul S; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Nyquist-Andersen M; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Herigstad ML; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Cantore A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Valacchi G; Department of Environmental Sciences and Prevention, University of Ferrara, Ferrara, Italy.; Department of Neurosciences and Rehabilitation; Animal Science Department, NC Research Campus, Plants for Human Health Institute, NC State University, Kannapolis, NC, USA.; Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea., Sandlie I; Department of Biosciences, University of Oslo, Oslo, Norway., Bernardi F; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Pinotti M; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Branchini A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. brnlss@unife.it., Andersen JT; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. j.t.andersen@medisin.uio.no.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no. |
| Source: | Nature communications [Nat Commun] 2025 Sep 29; Vol. 16 (1), pp. 8433. Date of Electronic Publication: 2025 Sep 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-62955-9 |
