Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis.
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| Title: | Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis. |
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| Authors: | Perriot S; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Jones S; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Genolet R; Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital and University of Lausanne, Agora Cancer Research Center, Lausanne, Switzerland.; Center for Cell Therapy, Lausanne University Hospital and University of Lausanne-Ludwig Institute for Cancer Research, Lausanne, Switzerland., Mathias A; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lindsay H; Biomedical Data Science Center, University of Lausanne and Lausanne University Hospital, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Bobisse S; Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital and University of Lausanne, Agora Cancer Research Center, Lausanne, Switzerland.; Center for Cell Therapy, Lausanne University Hospital and University of Lausanne-Ludwig Institute for Cancer Research, Lausanne, Switzerland., Di Liberto G; Department of Pathology and Immunology, Division of Clinical pathology, University and University Hospitals of Geneva, Geneva, Switzerland.; Service of Neurology, Department of Clinical Neurosciences, University Hospital of Lausanne and Lausanne University Hospital, Lausanne, Switzerland., Canales M; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Queiroz L; Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital and University of Lausanne, Agora Cancer Research Center, Lausanne, Switzerland.; Center for Cell Therapy, Lausanne University Hospital and University of Lausanne-Ludwig Institute for Cancer Research, Lausanne, Switzerland., Sauvage C; Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital and University of Lausanne, Agora Cancer Research Center, Lausanne, Switzerland.; Center for Cell Therapy, Lausanne University Hospital and University of Lausanne-Ludwig Institute for Cancer Research, Lausanne, Switzerland., Wagner I; Department of Pathology and Immunology, Division of Clinical pathology, University and University Hospitals of Geneva, Geneva, Switzerland., Oberholster L; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Gimenez M; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Bégarie D; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Kovac S; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Desestret V; French Reference Centre for Paraneoplastic Neurological Syndromes, Hospices Civils de Lyon; MeLis Institute, SynatAc Team, Inserm U1314/ UMR CNRS5284, Lyon, France., Théaudin M; Service of Neurology, Department of Clinical Neurosciences, University Hospital of Lausanne and Lausanne University Hospital, Lausanne, Switzerland., Pot C; Service of Neurology, Department of Clinical Neurosciences, University Hospital of Lausanne and Lausanne University Hospital, Lausanne, Switzerland., Wiendl H; Department of Neurology and Neurophysiology, University Medical Center, Freiburg, Germany., Honnorat J; French Reference Centre for Paraneoplastic Neurological Syndromes, Hospices Civils de Lyon; MeLis Institute, SynatAc Team, Inserm U1314/ UMR CNRS5284, Lyon, France., Merkler D; Department of Pathology and Immunology, Division of Clinical pathology, University and University Hospitals of Geneva, Geneva, Switzerland., Gottardo R; Biomedical Data Science Center, University of Lausanne and Lausanne University Hospital, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Harari A; Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital and University of Lausanne, Agora Cancer Research Center, Lausanne, Switzerland.; Center for Cell Therapy, Lausanne University Hospital and University of Lausanne-Ludwig Institute for Cancer Research, Lausanne, Switzerland., Du Pasquier R; Laboratory of Neuroimmunology, Neuroscience Research Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. renaud.du-pasquier@chuv.ch.; Service of Neurology, Department of Clinical Neurosciences, University Hospital of Lausanne and Lausanne University Hospital, Lausanne, Switzerland. renaud.du-pasquier@chuv.ch. |
| Source: | Nature communications [Nat Commun] 2025 Sep 29; Vol. 16 (1), pp. 8568. Date of Electronic Publication: 2025 Sep 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63573-1 |
