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Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort.

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Title: Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort.
Authors: Zhang BL; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Chen Y; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Zhang Y; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Qiao Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Wu Y; Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu, China., Zhang Y; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Lu Y; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., You X; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Li Y; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Huang HD; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Wang Q; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Li Y; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Wang Y; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Xiao W; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Duan H; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Qiu MH; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Chen NH; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Yu X; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Yang MM; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Lv L; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Cooper DN; Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK., Zheng P; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and Yunnan Engineering Center on Brain Disease Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Yao YG; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China. yaoyg@mail.kiz.ac.cn.; Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and Yunnan Engineering Center on Brain Disease Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn., Liu N; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China. liuning@ibp.ac.cn.; State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. liuning@ibp.ac.cn., Wang JH; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wangjh@mail.kiz.ac.cn.; Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and Yunnan Engineering Center on Brain Disease Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wangjh@mail.kiz.ac.cn., Wu DD; State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wudongdong@mail.kiz.ac.cn.; National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wudongdong@mail.kiz.ac.cn.; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wudongdong@mail.kiz.ac.cn.; Kunming Natural History Museum of Zoology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. wudongdong@mail.kiz.ac.cn.
Source: Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8703. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-63747-x