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Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers.

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Title: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers.
Authors: Tai MC; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.; Cancer Research Institute, Seoul National University, Jongno-gu, Seoul, Korea.; Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea., Kim SW; Department of Surgery, Daerim St. Mary's Hospital, Yeongdeungpo-gu, Seoul, Korea., Lee JW; Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Songpa-Gu, Seoul, Korea., Hassan NT; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia., Kwong A; Cancer Genetics Centre and Breast Surgery Centre, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong.; Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, Hong Kong.; Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong., Hartman M; Department of Surgery, National University Hospital and National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Yoon SY; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia., Ngeow J; Cancer Genetics Service, National Cancer Centre Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Woo YL; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Park B; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, South Korea., Wong ZL; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Barnes DR; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Parsons MT; Public Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Soucy P; Genomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada., Simard J; Genomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada., Mohd Taib NA; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; University Malaya Cancer Research Institute (UMCRI), University of Malaya, Kuala Lumpur, Kuala Lumpur, Malaysia., Yip CH; Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia.; Picaso Hospital, Petaling Jaya, Malaysia., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Chenevix-Trench G; Department of Haematology-Oncology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA, Australia., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Teo SH; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Ho WK; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. WeangKee.Ho@nottingham.edu.my.; School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia. WeangKee.Ho@nottingham.edu.my.
Source: NPJ breast cancer [NPJ Breast Cancer] 2025 Sep 30; Vol. 11 (1), pp. 105. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
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  Data: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers.
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  Data: <searchLink fieldCode="AU" term="%22Tai+MC%22">Tai MC</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Dennis+J%22">Dennis J</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Park+SK%22">Park SK</searchLink>; Department of Preventive Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.; Cancer Research Institute, Seoul National University, Jongno-gu, Seoul, Korea.; Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SW%22">Kim SW</searchLink>; Department of Surgery, Daerim St. Mary's Hospital, Yeongdeungpo-gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Songpa-Gu, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Hassan+NT%22">Hassan NT</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Kwong+A%22">Kwong A</searchLink>; Cancer Genetics Centre and Breast Surgery Centre, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong.; Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, Hong Kong.; Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Hartman+M%22">Hartman M</searchLink>; Department of Surgery, National University Hospital and National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yoon+SY%22">Yoon SY</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ngeow+J%22">Ngeow J</searchLink>; Cancer Genetics Service, National Cancer Centre Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Woo+YL%22">Woo YL</searchLink>; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Park+B%22">Park B</searchLink>; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Wong+ZL%22">Wong ZL</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Leslie+G%22">Leslie G</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bolla+MK%22">Bolla MK</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Barnes+DR%22">Barnes DR</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Parsons+MT%22">Parsons MT</searchLink>; Public Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Soucy+P%22">Soucy P</searchLink>; Genomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Simard+J%22">Simard J</searchLink>; Genomics Center, CHU de Québec-Université Laval Research Center, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Mohd+Taib+NA%22">Mohd Taib NA</searchLink>; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; University Malaya Cancer Research Institute (UMCRI), University of Malaya, Kuala Lumpur, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Yip+CH%22">Yip CH</searchLink>; Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia.; Picaso Hospital, Petaling Jaya, Malaysia.<br /><searchLink fieldCode="AU" term="%22Easton+DF%22">Easton DF</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chenevix-Trench+G%22">Chenevix-Trench G</searchLink>; Department of Haematology-Oncology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Antoniou+AC%22">Antoniou AC</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Teo+SH%22">Teo SH</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ho+WK%22">Ho WK</searchLink>; Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. WeangKee.Ho@nottingham.edu.my.; School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia. WeangKee.Ho@nottingham.edu.my.
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  Data: <searchLink fieldCode="JN" term="%22101674891%22">NPJ breast cancer</searchLink> [NPJ Breast Cancer] 2025 Sep 30; Vol. 11 (1), pp. 105. <i>Date of Electronic Publication: </i>2025 Sep 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Breast+Cancer+Research+Foundation%22">Breast Cancer Research Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101674891 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2374-4677 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223744677%22">23744677 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Breast Cancer <i>Subsets: </i>PubMed not MEDLINE
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