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S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models.

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Title: S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models.
Authors: Zhao S; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Song T; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Tang X; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Fan C; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Yang Y; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Zhang Z; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin 150081, China., Xia Y; Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.; Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China., Zhang Y; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Cao J; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Wang Z; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Shi Z; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Tang X; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.; Nanjing Medical University Drum Tower Clinical Medical College, Nanjing 210008, China., Wang D; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.; Nanjing Medical University Drum Tower Clinical Medical College, Nanjing 210008, China., Yin G; Department of Orthopaedics, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China., Zhang S; Department of Orthopaedics, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China., Gao Y; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Chen H; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Wang L; Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China., Chen F; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.; Department of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China., Wang H; Center for Metabolic Disease Research, Temple University School of Medicine, Philadelphia, PA 19140, USA., Yu B; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin 150081, China., Cao Y; Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.; Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China., Sun K; Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China., Liu X; Center for Zero-to-One Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China., Wang X; Center for Zero-to-One Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China., Yan C; State Key Laboratory of Frigid Zone Cardiovascular Diseases, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110003, China., Han Y; State Key Laboratory of Frigid Zone Cardiovascular Diseases, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110003, China., Han Y; Critical Care Department, Second Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China., Xie L; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China., Ji Y; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin 150081, China.
Source: Science translational medicine [Sci Transl Med] 2025 Oct; Vol. 17 (818), pp. eadn9216. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Song+T%22">Song T</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Fan+C%22">Fan C</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; 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Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.; Nanjing Medical University Drum Tower Clinical Medical College, Nanjing 210008, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; 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Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.; 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Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases; Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin 150081, China.
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