Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
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| Title: | Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. |
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| Authors: | Guo B; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA. bguo@fredhutch.org., Cai Y; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kim D; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Iyer KR; Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Hilliard AT; VA Palo Alto Health Care System, Palo Alto, CA, USA., Haessler J; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University of Medical Center, Nashville, TN, USA., Broadaway KA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wang Y; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pozdeyev N; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Stæger FF; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Yang C; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Patki AD; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Stalbow L; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lin M; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Shortt J; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Wiley L; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Stanislawski M; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Pattee J; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Davis L; Department of Medicine, Division of Data-Driven and Digital Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Straub PS; Vanderbilt Genetic Institute, Vanderbilt University of Medical Center, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine, Vanderbilt University of Medical Center, Nashville, TN, USA., Shuey MM; Vanderbilt Genetic Institute, Vanderbilt University of Medical Center, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine, Vanderbilt University of Medical Center, Nashville, TN, USA., Cox NJ; Vanderbilt Genetic Institute, Vanderbilt University of Medical Center, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine, Vanderbilt University of Medical Center, Nashville, TN, USA., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines., Jørgensen ME; Steno Diabetes Center Greenland, Nuuk, Greenland.; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Bjerregaard P; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Larsen C; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Moltke I; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Meigs JB; Department of Medicine, Mass General Brigham Healthcare System, Harvard Medical School, Boston, MA, USA., Stram DO; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yin X; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhou X; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Clarke SL; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA., Guarischi-Sousa R; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Lankester J; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Tsao PS; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Buyske S; Department of Genetics, Rutgers University, Piscataway, NJ, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sun Q; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Carlson CS; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Easton CB; Department of Epidemiology, School of Public Health, Brown University, Pawtucket, RI, USA.; Department of Family Medicine, Warren Alpert Medical School, Brown University, Pawtucket, RI, USA., Liu S; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA., Manson JE; Department of Medicine, Mass General Brigham Healthcare System, Harvard Medical School, Boston, MA, USA., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Albrechtsen A; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Manichaikul A; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Yousri NA; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.; Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Irvin RM; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Gignoux C; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Assimes TL; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Peters U; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Kooperberg C; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Raghavan S; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Medicine, Division of General Internal Medicine, University of Colorado School of Medicine, Denver, CO, USA., Highland HM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Darst BF; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA. bdarst@fredhutch.org. |
| Corporate Authors: | biobank at the Colorado Center for Personalized Medicine (CCPM), VA Million Veteran Program (MVP) |
| Source: | Nature communications [Nat Commun] 2025 Oct 01; Vol. 16 (1), pp. 8632. Date of Electronic Publication: 2025 Oct 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63546-4 |
