Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery.

Saved in:
Bibliographic Details
Title: Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery.
Authors: Murad JP; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Christian L; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Rosa R; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Ren Y; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Buckley AJ; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Lee EHJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory School of Medicine, Atlanta, GA, USA., Lopez LS; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Park AK; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Yang J; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Yamaguchi Y; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Trac C; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Adkins LN; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Chang WC; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Martinez C; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., June CH; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Forman SJ; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Ishihara J; Department of Bioengineering, Imperial College London, London, UK., Lee JK; Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA., Stern LA; Department of Chemical, Biological, and Materials Engineering, University of South Florida, Tampa, FL, USA., Priceman SJ; Keck School of Medicine (KSOM)/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Division of Medical Oncology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA. priceman@usc.edu.; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA. priceman@usc.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Apr; Vol. 10 (4), pp. 613-629. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01509-2