No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT.
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| Title: | No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT. |
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| Authors: | Delany-Moretlwe S; Wits RHI, University of Witwatersrand, Johannesburg, South Africa., Dehbi HM; Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Sikazwe I; Centre for Infectious Diseases Research in Zambia (CIDRZ), Lusaka, Zambia., Kyei G; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.; Washington University School of Medicine, St. Louis, MO, United States., Koram K; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Dubberke E; Washington University School of Medicine, St. Louis, MO, United States., Mwelase N; Clinical HIV Research Unit, University of Witwatersrand, Helen Joseph Hospital, Johannesburg, South Africa., Hague D; Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Bekker LG; Desmond Tutu Health Foundation, Cape Town, South Africa., Yun L; Washington University School of Medicine, St. Louis, MO, United States., Nel A; Medinel, Western Cape, South Africa., du Toit L; Washington University School of Medicine, St. Louis, MO, United States., Biccard B; Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa., Gill K; Desmond Tutu Health Foundation, Cape Town, South Africa., Chipeta C; Centre for Infectious Diseases Research in Zambia (CIDRZ), Lusaka, Zambia., Mngadi KT; The Aurum Institute, Johannesburg, South Africa., Lebina L; Wits RHI, University of Witwatersrand, Johannesburg, South Africa., Dassaye R; HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa., Asari V; HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa., Fry SH; Family Centre for Research with UBUNTU (FAMCRU), Stellenbosch University, Tygerberg, South Africa., Turton E; Department of Anesthesiology, University of the Free State, Free State, South Africa., Ahmed K; Setshaba Research Centre, Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa., Kusi K; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Adu-Amankwah S; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Chilengi R; Centre for Infectious Diseases Research in Zambia (CIDRZ), Lusaka, Zambia., Chilekwa JC; Centre for Infectious Diseases Research in Zambia (CIDRZ), Lusaka, Zambia., Lovat L; Center for Perioperative Medicine, Department of Targeted Intervention, University College London, London, United Kingdom., McGuckin D; Center for Perioperative Medicine, Department of Targeted Intervention, University College London, London, United Kingdom., Caverly E; Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Politi M; Washington University School of Medicine, St. Louis, MO, United States., Swan B; Washington University School of Medicine, St. Louis, MO, United States., DeSchryver A; Washington University School of Medicine, St. Louis, MO, United States., McKinnon S; Washington University School of Medicine, St. Louis, MO, United States., Gupta A; Washington University School of Medicine, St. Louis, MO, United States., Jones G; Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Freemantle N; Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Khader S; Washington University School of Medicine, St. Louis, MO, United States., Rees H; Wits RHI, University of Witwatersrand, Johannesburg, South Africa., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Moonesinghe SR; Center for Perioperative Medicine, Department of Targeted Intervention, University College London, London, United Kingdom., Avidan MS; Washington University School of Medicine, St. Louis, MO, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Sep 16; Vol. 16, pp. 1588190. Date of Electronic Publication: 2025 Sep 16 (Print Publication: 2025). |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1588190 |
