APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.

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Title: APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.
Authors: Shan C; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Cong R; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Xu X; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Li Y; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Tian Y; School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China., Cao W; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Zhao W; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710061, China., Miao L; Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China., Teng J; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Huang N; Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China., Chen J; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.; Center for Quantitative Biology, Peking University, Beijing 100871, China.
Source: Journal of molecular cell biology [J Mol Cell Biol] 2026 Mar 02; Vol. 17 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101503669 Publication Model: Print Cited Medium: Internet ISSN: 1759-4685 (Electronic) Linking ISSN: 17594685 NLM ISO Abbreviation: J Mol Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1759-4685
DOI:10.1093/jmcb/mjaf033