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APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.

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Title: APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.
Authors: Shan C; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Cong R; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Xu X; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Li Y; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Tian Y; School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China., Cao W; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Zhao W; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710061, China., Miao L; Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China., Teng J; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China., Huang N; Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China., Chen J; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.; Center for Quantitative Biology, Peking University, Beijing 100871, China.
Source: Journal of molecular cell biology [J Mol Cell Biol] 2026 Mar 02; Vol. 17 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101503669 Publication Model: Print Cited Medium: Internet ISSN: 1759-4685 (Electronic) Linking ISSN: 17594685 NLM ISO Abbreviation: J Mol Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.
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  Data: <searchLink fieldCode="AU" term="%22Shan+C%22">Shan C</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Cong+R%22">Cong R</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Cao+W%22">Cao W</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Miao+L%22">Miao L</searchLink>; Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China.<br /><searchLink fieldCode="AU" term="%22Teng+J%22">Teng J</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Huang+N%22">Huang N</searchLink>; Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China.; Center for Quantitative Biology, Peking University, Beijing 100871, China.
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  Data: <searchLink fieldCode="JN" term="%22101503669%22">Journal of molecular cell biology</searchLink> [J Mol Cell Biol] 2026 Mar 02; Vol. 17 (8).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101503669 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1759-4685 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217594685%22">17594685 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41055405
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        Value: 10.1093/jmcb/mjaf033
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      – Code: eng
        Text: English
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      – TitleFull: APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation.
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            – D: 02
              M: 03
              Text: 2026 Mar 02
              Type: published
              Y: 2026
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