Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.

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Title: Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.
Authors: Nordestgaard LT; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Hanson A; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Sanderson E; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Anderson E; Division of Psychiatry, University College London, London, UK., Walker V; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Tybjærg-Hansen A; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark., Smith GD; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Nordestgaard BG; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70638.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1552-5279
DOI:10.1002/alz.70638