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Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.

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Title: Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.
Authors: Nordestgaard LT; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Hanson A; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Sanderson E; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Anderson E; Division of Psychiatry, University College London, London, UK., Walker V; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Tybjærg-Hansen A; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark., Smith GD; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Nordestgaard BG; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70638.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.
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  Data: <searchLink fieldCode="AU" term="%22Nordestgaard+LT%22">Nordestgaard LT</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hanson+A%22">Hanson A</searchLink>; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Sanderson+E%22">Sanderson E</searchLink>; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Anderson+E%22">Anderson E</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Walker+V%22">Walker V</searchLink>; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Tybjærg-Hansen+A%22">Tybjærg-Hansen A</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.<br /><searchLink fieldCode="AU" term="%22Smith+GD%22">Smith GD</searchLink>; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Nordestgaard+BG%22">Nordestgaard BG</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; The Copenhagen General Population Study, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Copenhagen City Heart Study, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70638.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.70638
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        Text: English
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            – D: 01
              M: 10
              Text: 2025 Oct
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              Y: 2025
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