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Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases.

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Title: Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases.
Authors: Keenan BP; Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Qiao G; Department of Surgery, Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Kunda N; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA., Kone L; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA., Guldberg SM; Departments of Otolaryngology-Head and Neck Surgery and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA., Todeschini L; Department of Surgery, Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Kumar P; Department of Microbiology & Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA., Pollini T; Department of Surgery, Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Hernandez S; Department of Surgery, Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Qin J; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA., Fong L; Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA., Spitzer MH; Departments of Otolaryngology-Head and Neck Surgery and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Prabhakar BS; Department of Microbiology & Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA., Maker AV; Department of Surgery, Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA 94143, USA.
Source: Science advances [Sci Adv] 2025 Oct 10; Vol. 11 (41), pp. eadv9161. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases.
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