MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists.
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| Title: | MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists. |
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| Authors: | Hsu JM; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan., Liu C; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xia W; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan., Chen CY; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan., Cheng WC; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, China Medical University, Taichung, Taiwan., Hou J; Department of Otolaryngology Head and Neck Surgery and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China., Hung MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan. |
| Source: | Science (New York, N.Y.) [Science] 2025 Oct 09; Vol. 390 (6769), pp. eadl4089. Date of Electronic Publication: 2025 Oct 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adl4089 |
