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MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists.

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Title: MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists.
Authors: Hsu JM; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan., Liu C; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xia W; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan., Chen CY; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan., Cheng WC; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, China Medical University, Taichung, Taiwan., Hou J; Department of Otolaryngology Head and Neck Surgery and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China., Hung MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.
Source: Science (New York, N.Y.) [Science] 2025 Oct 09; Vol. 390 (6769), pp. eadl4089. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists.
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  Data: <searchLink fieldCode="AU" term="%22Hsu+JM%22">Hsu JM</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+WC%22">Cheng WC</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Department of Otolaryngology Head and Neck Surgery and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Hung+MC%22">Hung MC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Molecular Medicine, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2025 Oct 09; Vol. 390 (6769), pp. eadl4089. <i>Date of Electronic Publication: </i>2025 Oct 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
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        Value: 10.1126/science.adl4089
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        Text: English
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              Text: 2025 Oct 09
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