Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial.

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Title: Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial.
Authors: Paterson DL; ADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia. Electronic address: uqdpate1@nus.edu.sg., Sulaiman H; Department of Medicine, Infectious Diseases Unit, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Liu PY; Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan., Chatfield MD; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Yilmaz M; Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Istanbul Medipol University, Istanbul, Türkiye; School of Medicine, Istanbul Medipol University, Istanbul, Türkiye., Salmuna ZN; Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia., Mazlan MZ; Department of Anaesthesiology and Intensive Care, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia., Anunnatsiri S; Department of Medicine, Division of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Sirijatuphat R; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Chotiprasitsakul D; Department of Medicine, Division of Infectious Diseases, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Microbiology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Lye DC; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Infectious Diseases, National Centre for Infectious Diseases, Singapore., Somani J; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine, Division of Infectious Diseases, National University Hospital, Singapore., Kalimuddin S; Department of Infectious Diseases, Singapore General Hospital, Singapore; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore., Aslan AT; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Thamlikitkul V; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Lee YT; Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Yang YS; Department of Internal Medicine, Division of Infectious Diseases and Tropical Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Lin YT; Department of Medicine, Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Ramli WNW; Department of Internal Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Gambang, Malaysia., Tseng CH; Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan., Archuleta S; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine, Division of Infectious Diseases, National University Hospital, Singapore., Chan YFZ; Department of Infectious Diseases, Singapore General Hospital, Singapore., Forde BM; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Wright H; Department of Infectious Disease, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia., Stewart AG; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Ramsay KA; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Ling W; ADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Rossi V; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Harris-Brown TM; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Harris PNA; ADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia; Department of Infectious Disease, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia; Pathology Queensland, Central Microbiology, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia.
Corporate Authors: GAME CHANGER Trial Investigators
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2026 Feb; Vol. 26 (2), pp. 148-159. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-4457
DOI:10.1016/S1473-3099(25)00469-4