HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs.

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Title: HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs.
Authors: Kulkarni K; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Quinn G; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Dela Rosa J; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Goetsch S; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Pandit V; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Wang L; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Sakaguchi A; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Sivakumar S; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Munshi NV; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA. Nikhil.Munshi@utsouthwestern.edu.; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Nikhil.Munshi@utsouthwestern.edu.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Nikhil.Munshi@utsouthwestern.edu.; McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. Nikhil.Munshi@utsouthwestern.edu.; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. Nikhil.Munshi@utsouthwestern.edu.
Source: Nature communications [Nat Commun] 2025 Oct 10; Vol. 16 (1), pp. 9024. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64076-9