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The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD.

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Title: The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD.
Authors: Lu B; Discovery Sciences, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA., Cong F; Discovery Sciences, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
Source: Science signaling [Sci Signal] 2025 Oct 14; Vol. 18 (908), pp. eadv1529. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lu+B%22">Lu B</searchLink>; Discovery Sciences, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cong+F%22">Cong F</searchLink>; Discovery Sciences, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2025 Oct 14; Vol. 18 (908), pp. eadv1529. <i>Date of Electronic Publication: </i>2025 Oct 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101465400 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1937-9145 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219450877%22">19450877 </searchLink><i>NLM ISO Abbreviation: </i>Sci Signal <i>Subsets: </i>MEDLINE
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        Value: 10.1126/scisignal.adv1529
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      – TitleFull: The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD.
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              Text: 2025 Oct 14
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