Microenvironmental regulation of solid tumour resistance to CAR T cell therapy.

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Title: Microenvironmental regulation of solid tumour resistance to CAR T cell therapy.
Authors: Lamplugh ZL; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Wellhausen N; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Translational Center of Excellence in Hematopoietic Stem Cell Engineering, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., June CH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu., Fan Y; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA. fanyi@upenn.edu.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. fanyi@upenn.edu.
Source: Nature reviews. Immunology [Nat Rev Immunol] 2026 Mar; Vol. 26 (3), pp. 230-248. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1741 (Electronic) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-1741
DOI:10.1038/s41577-025-01229-3