Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.
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| Title: | Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation. |
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| Authors: | Takei T; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Sasazawa Y; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan., Noshiro D; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Kitagawa M; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Kataura T; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Hirawake-Mogi H; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan., Kawauchi E; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Nakano Y; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Tashiro E; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Laboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan., Saitoh T; Department of Chemistry, Keio University, Kanagawa, Japan.; Institute of Medicine, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan., Nishiyama S; Department of Chemistry, Keio University, Kanagawa, Japan., Ogawa S; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Kakuta S; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kazuno S; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Miura Y; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Taniguchi D; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan., Korolchuk VI; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Noda NN; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Saiki S; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Imoto M; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan. m.imoto.xz@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp., Hattori N; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan. nhattori@juntendo.ac.jp. |
| Source: | The EMBO journal [EMBO J] 2025 Nov; Vol. 44 (22), pp. 6527-6555. Date of Electronic Publication: 2025 Oct 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00591-1 |
