View in EDS HTML Full Text PDF Full Text

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.

Saved in:
Bibliographic Details
Title: Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.
Authors: Takei T; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Sasazawa Y; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan., Noshiro D; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Kitagawa M; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Kataura T; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Hirawake-Mogi H; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan., Kawauchi E; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Nakano Y; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Tashiro E; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Laboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan., Saitoh T; Department of Chemistry, Keio University, Kanagawa, Japan.; Institute of Medicine, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan., Nishiyama S; Department of Chemistry, Keio University, Kanagawa, Japan., Ogawa S; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan., Kakuta S; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kazuno S; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Miura Y; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan., Taniguchi D; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan., Korolchuk VI; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Noda NN; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan., Saiki S; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan., Imoto M; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan. m.imoto.xz@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp., Hattori N; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan. nhattori@juntendo.ac.jp.
Source: The EMBO journal [EMBO J] 2025 Nov; Vol. 44 (22), pp. 6527-6555. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41087580
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Takei+T%22">Takei T</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Sasazawa+Y%22">Sasazawa Y</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Noshiro+D%22">Noshiro D</searchLink>; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kitagawa+M%22">Kitagawa M</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kataura+T%22">Kataura T</searchLink>; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Hirawake-Mogi+H%22">Hirawake-Mogi H</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawauchi+E%22">Kawauchi E</searchLink>; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano+Y%22">Nakano Y</searchLink>; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Tashiro+E%22">Tashiro E</searchLink>; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.; Laboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saitoh+T%22">Saitoh T</searchLink>; Department of Chemistry, Keio University, Kanagawa, Japan.; Institute of Medicine, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishiyama+S%22">Nishiyama S</searchLink>; Department of Chemistry, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kakuta+S%22">Kakuta S</searchLink>; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kazuno+S%22">Kazuno S</searchLink>; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miura+Y%22">Miura Y</searchLink>; Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+D%22">Taniguchi D</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Korolchuk+VI%22">Korolchuk VI</searchLink>; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Noda+NN%22">Noda NN</searchLink>; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Saiki+S%22">Saiki S</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Neurology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Imoto+M%22">Imoto M</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp.; Department of Biosciences and Informatics, Keio University, Kanagawa, Japan. m.imoto.xz@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. m.imoto.xz@juntendo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hattori+N%22">Hattori N</searchLink>; Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Division for Development of Autophagy Modulating Drugs, Juntendo University Faculty of Medicine, Tokyo, Japan. nhattori@juntendo.ac.jp.; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan. nhattori@juntendo.ac.jp.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2025 Nov; Vol. 44 (22), pp. 6527-6555. <i>Date of Electronic Publication: </i>2025 Oct 14.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8208664 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2075 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202614189%22">02614189 </searchLink><i>NLM ISO Abbreviation: </i>EMBO J <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41087580
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44318-025-00591-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 6527
    Titles:
      – TitleFull: Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Takei T
      – PersonEntity:
          Name:
            NameFull: Sasazawa Y
      – PersonEntity:
          Name:
            NameFull: Noshiro D
      – PersonEntity:
          Name:
            NameFull: Kitagawa M
      – PersonEntity:
          Name:
            NameFull: Kataura T
      – PersonEntity:
          Name:
            NameFull: Hirawake-Mogi H
      – PersonEntity:
          Name:
            NameFull: Kawauchi E
      – PersonEntity:
          Name:
            NameFull: Nakano Y
      – PersonEntity:
          Name:
            NameFull: Tashiro E
      – PersonEntity:
          Name:
            NameFull: Saitoh T
      – PersonEntity:
          Name:
            NameFull: Nishiyama S
      – PersonEntity:
          Name:
            NameFull: Ogawa S
      – PersonEntity:
          Name:
            NameFull: Kakuta S
      – PersonEntity:
          Name:
            NameFull: Kazuno S
      – PersonEntity:
          Name:
            NameFull: Miura Y
      – PersonEntity:
          Name:
            NameFull: Taniguchi D
      – PersonEntity:
          Name:
            NameFull: Korolchuk VI
      – PersonEntity:
          Name:
            NameFull: Noda NN
      – PersonEntity:
          Name:
            NameFull: Saiki S
      – PersonEntity:
          Name:
            NameFull: Imoto M
      – PersonEntity:
          Name:
            NameFull: Hattori N
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2025 Nov
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2075
          Numbering:
            – Type: volume
              Value: 44
            – Type: issue
              Value: 22
          Titles:
            – TitleFull: The EMBO journal
              Type: main
ResultId 1