Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells.

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Title: Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells.
Authors: Pucella JN; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Joseph.Pucella@nyulangone.org.; Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Joseph.Pucella@nyulangone.org., Maqueda-Alfaro RA; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA., Ni H; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA., Bandeira Sulczewski F; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA., Eichinger A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Esteva E; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Ra AC; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Das A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Perez OA; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Feng J; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Stoeckius M; Technology Innovation Lab, New York Genome Center, New York, NY, USA., Smibert P; Technology Innovation Lab, New York Genome Center, New York, NY, USA., Khodadadi-Jamayran A; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Dolgalev I; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Ivanova E; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Sota S; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Cadwell K; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Koralov SB; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Zhong J; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA., Soni C; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Stetson DB; Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Weisberg SP; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Idoyaga J; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA. jidoyaga@health.ucsd.edu.; Department of Molecular Biology, University of California San Diego School of Biological Sciences, San Diego, CA, USA. jidoyaga@health.ucsd.edu., Reizis B; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Boris.Reizis@nyulangone.org.
Source: Nature immunology [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 1946-1961. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells.
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  Data: <searchLink fieldCode="AU" term="%22Pucella+JN%22">Pucella JN</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Joseph.Pucella@nyulangone.org.; Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Joseph.Pucella@nyulangone.org.<br /><searchLink fieldCode="AU" term="%22Maqueda-Alfaro+RA%22">Maqueda-Alfaro RA</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ni+H%22">Ni H</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bandeira+Sulczewski+F%22">Bandeira Sulczewski F</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eichinger+A%22">Eichinger A</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Esteva+E%22">Esteva E</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ra+AC%22">Ra AC</searchLink>; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Das+A%22">Das A</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Perez+OA%22">Perez OA</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stoeckius+M%22">Stoeckius M</searchLink>; Technology Innovation Lab, New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smibert+P%22">Smibert P</searchLink>; Technology Innovation Lab, New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Khodadadi-Jamayran+A%22">Khodadadi-Jamayran A</searchLink>; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dolgalev+I%22">Dolgalev I</searchLink>; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ivanova+E%22">Ivanova E</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sota+S%22">Sota S</searchLink>; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cadwell+K%22">Cadwell K</searchLink>; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Koralov+SB%22">Koralov SB</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Soni+C%22">Soni C</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stetson+DB%22">Stetson DB</searchLink>; Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Weisberg+SP%22">Weisberg SP</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Farber+DL%22">Farber DL</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Idoyaga+J%22">Idoyaga J</searchLink>; Department of Pharmacology, University of California San Diego School of Medicine, San Diego, CA, USA. jidoyaga@health.ucsd.edu.; Department of Molecular Biology, University of California San Diego School of Biological Sciences, San Diego, CA, USA. jidoyaga@health.ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Reizis+B%22">Reizis B</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Boris.Reizis@nyulangone.org.
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