Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.

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Title: Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.
Authors: Katsuda Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp., Kamura T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Kida T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Ohno R; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Shiroto S; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Hasegawa Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Utsumi K; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Sakamoto Y; Faculty of Medicine, Osaka University, Osaka, Japan., Nakamura S; Priority Organization for Innovation and Excellence Laboratory for Data Science, Kumamoto University, Kumamoto, Japan., Nakamura T; Department of Medical Information Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Tsujita K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Kitamura Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Kamiya Y; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.; Laboratory of Bioanalytical Chemistry, Kobe Pharmaceutical University, Kobe, Japan., Asanuma H; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan., Ihara T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. toshi@chem.kumamoto-u.ac.jp., Hagihara M; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan. hagihara@hirosaki-u.ac.jp., Sato SI; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; Institute for Chemical Research, Kyoto University, Kyoto, Japan. ssato0222@kumamoto-u.ac.jp.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Jun; Vol. 10 (6), pp. 1124-1135. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01515-4