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Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.

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Title: Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.
Authors: Katsuda Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp., Kamura T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Kida T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Ohno R; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Shiroto S; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Hasegawa Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Utsumi K; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan., Sakamoto Y; Faculty of Medicine, Osaka University, Osaka, Japan., Nakamura S; Priority Organization for Innovation and Excellence Laboratory for Data Science, Kumamoto University, Kumamoto, Japan., Nakamura T; Department of Medical Information Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Tsujita K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Kitamura Y; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Kamiya Y; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.; Laboratory of Bioanalytical Chemistry, Kobe Pharmaceutical University, Kobe, Japan., Asanuma H; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan., Ihara T; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. toshi@chem.kumamoto-u.ac.jp., Hagihara M; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan. hagihara@hirosaki-u.ac.jp., Sato SI; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; Institute for Chemical Research, Kyoto University, Kyoto, Japan. ssato0222@kumamoto-u.ac.jp.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Jun; Vol. 10 (6), pp. 1124-1135. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Katsuda+Y%22">Katsuda Y</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. katsuda2243@kumamoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Kamura+T%22">Kamura T</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kida+T%22">Kida T</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ohno+R%22">Ohno R</searchLink>; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan.<br /><searchLink fieldCode="AU" term="%22Shiroto+S%22">Shiroto S</searchLink>; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan.<br /><searchLink fieldCode="AU" term="%22Hasegawa+Y%22">Hasegawa Y</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Utsumi+K%22">Utsumi K</searchLink>; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamoto+Y%22">Sakamoto Y</searchLink>; Faculty of Medicine, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+S%22">Nakamura S</searchLink>; Priority Organization for Innovation and Excellence Laboratory for Data Science, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+T%22">Nakamura T</searchLink>; Department of Medical Information Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tsujita+K%22">Tsujita K</searchLink>; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamura+Y%22">Kitamura Y</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kamiya+Y%22">Kamiya Y</searchLink>; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.; Laboratory of Bioanalytical Chemistry, Kobe Pharmaceutical University, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Asanuma+H%22">Asanuma H</searchLink>; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Ihara+T%22">Ihara T</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. toshi@chem.kumamoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hagihara+M%22">Hagihara M</searchLink>; Graduate School of Science and Technology, Hirosaki University, Aomori, Japan. hagihara@hirosaki-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Sato+SI%22">Sato SI</searchLink>; Division of Materials Science and Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; StapleBio Inc., Kumamoto, Japan. ssato0222@kumamoto-u.ac.jp.; Institute for Chemical Research, Kyoto University, Kyoto, Japan. ssato0222@kumamoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2026 Jun; Vol. 10 (6), pp. 1124-1135. <i>Date of Electronic Publication: </i>2025 Oct 15.
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