Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice.
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| Title: | Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice. |
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| Authors: | Torres JM; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Marín-Moreno A; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Espinosa JC; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain., Canoyra S; Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense de Madrid UCM, Madrid, Spain., Burato A; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy., Ciullini A; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., De Luca CMG; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Bistaffa E; Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Moda F; Unit of Laboratory of Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Legname G; Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.; ELETTRA Sincrotrone Trieste S.C.p.A, Basovizza, Trieste, Italy. |
| Source: | PLoS pathogens [PLoS Pathog] 2025 Oct 16; Vol. 21 (10), pp. e1013554. Date of Electronic Publication: 2025 Oct 16 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7374 |
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| DOI: | 10.1371/journal.ppat.1013554 |
